Chemokine

Recombinant Human RANTES (CCL5)

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Product Details

Catalogue Number: 300-06
Description:

RANTES is a CC chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant Human RANTES is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta

AA Sequence: SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 1.0-10.0 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: P13501

Gene ID: 6352

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Urbinati, C
Title
HIV-1 Tat and heparan sulfate proteoglycan interaction: a novel mechanism of lymphocyte adhesion and migration across the endothelium.
Citation
Blood; 114(15) pg3335-42
PubMed Id
First Author
Zhang, Y
Title
A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.
Citation
Scientific Reports; 7(1) pg15038
PubMed Id
First Author
Trkola, A
Title
HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 99(1) pg395-400
PubMed Id