Chemokine

Recombinant Human RANTES (CCL5)

Product Details

Catalogue Number: 300-06
Description:

RANTES is a CC chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant Human RANTES is a 7.8 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Regulation upon Activation Normal T cell Express Sequence, CCL5, SIS-delta

AA Sequence: SPYSSDTTPC CFAYIARPLP RAHIKEYFYT SGKCSNPAVV FVTRKNRQVC ANPEKKWVRE YINSLEMS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human blood monocytes using a concentration range of 1.0-10.0 ng/ml.

Calculated Molecular Weight: 7.8 kDa

Accession Number: P13501

Gene ID: 6352

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Wolff, E A
Title
Generation of artificial proteoglycans containing glycosaminoglycan-modified CD44. Demonstration of the interaction between rantes and chondroitin sulfate.
Citation
The Journal of Biological Chemistry; 274(4) pg2518-24
PubMed Id
First Author
Shen, H
Title
Intrinsic human immunodeficiency virus type 1 resistance of hematopoietic stem cells despite coreceptor expression.
Citation
Journal of Virology; 73(1) pg728-37
PubMed Id
First Author
Wang, J M
Title
HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(8) pg4309-17
PubMed Id