Chemokine

Recombinant Human SDF-1β (CXCL12)

Product Details

Catalogue Number: 300-28B
Description:

SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1β protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Human SDF-1β is an 8.5 kDa protein containing 72 amino acid residues.

Source: E.coli

Synonyms: Stromal-Cell Derived Factor-1, CXCL12, PBSF

AA Sequence: KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRF KM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract activated human T-lymphocytes using a concentration range of 10-50 ng/ml.

Calculated Molecular Weight: 8.5 kDa

Accession Number: P48061

Gene ID: 6387

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Campbell, J J
Title
Chemokines and the arrest of lymphocytes rolling under flow conditions.
Citation
Science (New York, N.Y.); 279(5349) pg381-4
PubMed Id
First Author
Colado, A
Title
Immunomodulatory effects of different intravenous immunoglobulin preparations in chronic lymphocytic leukemia.
Citation
Scientific Reports; 11(1) pg12926
PubMed Id
First Author
Gimenez, N
Title
Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia
Citation
Scientific Reports; 10(1) pg22153
PubMed Id