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Recombinant Human sRANK Ligand (CHO derived)

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Katalognummer: 310-01C
Beschreibung:
Recombinant Human sRANK Ligand (CHO derived)

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK+ T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells,including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Human RANKL is reactive on murine cells. PeproTech's CHO cell-derived Recombinant Human sRANK Ligand is a 22.1 kDa polypeptide comprised of the TNF-homologous region of RANKL and a N-terminal His-tag.

Source: CHO cells

Synonyms: soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-Related Activation-induced Cytokine), OPGL, ODF (Osteoclast Differentiation Factor), CD254

AA Sequence: HHHHHHHHPS PGGSGGSQHI RAEKAMVDGS WLDLAKRSKL EAQPFAHLTI NATDIPSGSH KVSLSSWYHD RGWGKISNMT FSNGKLIVNQ DGFYYLYANI CFRHHETSGD LATEYLQLMV YVTKTSIKIP SSHTLMKGGS TKYWSGNSEF HFYSINVGGF FKLRSGEEIS IEVSNPSLLD PDQDATYFGA FKVRDID

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its dose-dependent ability to induce reporter gene in HT-29 NF-κB Luc reporter cells.

Recombinant Human sRANK Ligand (CHO derived) Biological Activity Graph

Calculated Molecular Weight: 22.1 kDa

Accession Number: O14788

Gene ID: 8600

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

Erstautor
Kaur, K
Titel
Osteoclast-expanded super-charged NK-cells preferentially select and expand CD8+ T cells.
Literaturstelle
Scientific Reports; 10(1) pg20363
PubMed ID
Erstautor
Yang, B
Titel
Amyloid β peptide promotes bone formation by regulating Wnt/β-catenin signaling and the OPG/RANKL/RANK system.
Literaturstelle
ACR Open Rheumatology; 34(3) pg3583-3593
PubMed ID
Erstautor
Weivoda, M
Titel
Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism.
Literaturstelle
Nature Communications; 11(1) pg87
PubMed ID