Recombinant Human VEGF121 1 ReviewsSubmit a Review Product Details Catalogue Number: 100-20A Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant Human VEGF121 is a 28.4 kDa, disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains. Source: E.coli Synonyms: Vascular Endothelial Growth Factor 121, VPF, VEGF-A AA Sequence (monomer): APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR R Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2-0.4 ng/ml. Calculated Molecular Weight: 28.4 kDa Accession Number: P15692 Gene ID: 7422 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Chicken, Dog, Human, Mouse, Rabbit, Rat, Sheep References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Hu, L Title Endothelial cell-derived Apelin inhibits tumor growth by altering immune cell localization Citation Scientific Reports; 11(1) pg14047 PubMed Id 34234274 First Author Cohen, S Title Generation of vascular chimerism within donor organs Citation Scientific Reports; 11(1) pg13437 PubMed Id 34183759 First Author Seki, T Title Interleukin-6 as an enhancer of anti-angiogenic therapy for ovarian clear cell carcinoma Citation Scientific Reports; 11(1) pg7689 PubMed Id 33833265 product.subtitle.productreviews Existing reviews high quality product for vascular biology research We use this product in our project for more than 5 years, by which the hiPSC-derived vascular endothelial cell were differentiated From: Ping | Date: 26.08.2020 × high quality product for vascular biology research We use this product in our project for more than 5 years, by which the hiPSC-derived vascular endothelial cell were differentiated From: Ping | Date: 26.08.2020 Close
