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“Animal-Free” Zytokine

Animal-Free Recombinant Human VEGF121

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Produktdetails

Katalognummer: AF-100-20A
Beschreibung:
Animal-Free Recombinant Human VEGF 121

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant Human VEGF121 is a 28.4 kDa, disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Vascular Endothelial Growth Factor 121, VPF, VEGF-A

AA Sequence (monomer): APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR R

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Calculated Molecular Weight: 28.4 kDa

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2-0.4 ng/ml.

Animal-Free Recombinant Human VEGF 121 Biological Activity Graph

Accession Number: P15692

Gene ID: 7422

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

Erstautor
Szczepkowska, A
Titel
Pattern of expression of vascular endothelial growth factor and its receptors in the ovine choroid plexus during long and short photoperiods.
Literaturstelle
Cell and Tissue Research; 350(1) pg157-66
PubMed ID
Erstautor
Ferro, F
Titel
Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics.
Literaturstelle
PLoS ONE; 7(7) pge41774
PubMed ID
Erstautor
Sachdeva, R
Titel
Transgenesis-mediated reproductive dysfunction and tumorigenesis: effects of immunological neutralization.
Literaturstelle
PLoS ONE; 7(11) pge51125
PubMed ID