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“Animal-Free” Zytokine

Animal-Free Recombinant Human VEGF165

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Product Details

Catalogue Number: AF-100-20
Description:
Animal-Free Recombinant Human VEGF 165

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Human VEGF165 is a 38.2 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Vascular Endothelial Growth Factor, VPF, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF-A

AA Sequence (monomer): APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-8.0 ng/ml.

This product has been tested against the WHO standard. International Unit information can be found here.

Animal-Free Recombinant Human VEGF 165 Biological Activity Graph Animal-Free Recombinant Human VEGF 165 WHO Comparison Graph

Calculated Molecular Weight: 38.2 kDa

Accession Number: P15692

Gene ID: 7422

Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Hofbauer, P
Title
Cardioids reveal self-organizing principles of human cardiogenesis.
Citation
Cell; 184(12) pg3299-3317.e22
PubMed Id
First Author
Choi, D K
Title
The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells
Citation
Scientific Reports; 10(1) pg12089
PubMed Id
First Author
Tiburcy, M
Title
Generation of Engineered Human Myocardium in a Multi-well Format.
Citation
STAR Protocols; 1(1) pg100032
PubMed Id