Recombinant Murine Eotaxin (CCL11) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-01 Description: Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Murine Eotaxin is an 8.4 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: CCL11 AA Sequence: HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Murine Eotaxin was found to induce chemotaxis of purified eosinophils at concentrations ranging between 10-100 ng/ml. Calculated Molecular Weight: 8.4 kDa Accession Number: P48298 Gene ID: 20292 crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Neurobiology Wound Healing product.subtitle.recentcitations First Author Wen, T Title Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo. Citation Proceedings of the National Academy of Sciences of the United States of America; 110(15) pg6067-72 PubMed Id 23536294 First Author Tager, A M Title BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. Citation The Journal of Experimental Medicine; 192(3) pg439-46 PubMed Id 10934232 First Author Wright, D E Title Hematopoietic stem cells are uniquely selective in their migratory response to chemokines. Citation The Journal of Experimental Medicine; 195(9) pg1145-54 PubMed Id 11994419
