Chemokine

Recombinant Murine Eotaxin (CCL11)

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Product Details

Catalogue Number: 250-01
Description:

Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Murine Eotaxin is an 8.4 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: CCL11

AA Sequence: HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Murine Eotaxin was found to induce chemotaxis of purified eosinophils at concentrations ranging between 10-100 ng/ml.

Calculated Molecular Weight: 8.4 kDa

Accession Number: P48298

Gene ID: 20292

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Wen, T
Title
Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 110(15) pg6067-72
PubMed Id
First Author
Tager, A M
Title
BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis.
Citation
The Journal of Experimental Medicine; 192(3) pg439-46
PubMed Id
First Author
Wright, D E
Title
Hematopoietic stem cells are uniquely selective in their migratory response to chemokines.
Citation
The Journal of Experimental Medicine; 195(9) pg1145-54
PubMed Id