Recombinant Murine Eotaxin (CCL11) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-01 Description: Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Murine Eotaxin is an 8.4 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: CCL11 AA Sequence: HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Murine Eotaxin was found to induce chemotaxis of purified eosinophils at concentrations ranging between 10-100 ng/ml. Calculated Molecular Weight: 8.4 kDa Accession Number: P48298 Gene ID: 20292 crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Neurobiology Wound Healing product.subtitle.recentcitations First Author Peled, A Title The chemotactic cytokine eotaxin acts as a granulocyte-macrophage colony-stimulating factor during lung inflammation. Citation Blood; 91(6) pg1909-16 PubMed Id 9490673 First Author Sarafi, M N Title Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. Citation The Journal of Experimental Medicine; 185(1) pg99-109 PubMed Id 8996246 First Author Felton, J M Title Aiolos regulates eosinophil migration into tissues Citation Mucosal Immunology; 14(6) pg1271-1281 PubMed Id 34341502
