Chemokine

Recombinant Murine Eotaxin (CCL11)

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Product Details

Catalogue Number: 250-01
Description:
Recombinant Murine Eotaxin (CCL11)

Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Murine Eotaxin is an 8.4 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: CCL11

AA Sequence: HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Murine Eotaxin was found to induce chemotaxis of purified eosinophils at concentrations ranging between 10-100 ng/ml.

Calculated Molecular Weight: 8.4 kDa

Accession Number: P48298

Gene ID: 20292

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Felton, J M
Title
Aiolos regulates eosinophil migration into tissues
Citation
Mucosal Immunology; 14(6) pg1271-1281
PubMed Id
First Author
Patial, S
Title
Myeloid-IL4Rα is an indispensable link in IL-33-ILCs-IL-13-IL4Rα axis of eosinophil recruitment in murine lungs.
Citation
Scientific Reports; 11(1) pg15465
PubMed Id
First Author
Dileepan, M
Title
Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A.
Citation
Journal of Immunology; 204(3) pg682-693
PubMed Id