Recombinant Murine IL-1α 0 ReviewsSubmit a Review Product Details Catalogue Number: 211-11A Description: IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Murine IL-1α is a 17.9 kDa protein containing 156 amino acid residues. Source: E.coli Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) AA Sequence: SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg. Calculated Molecular Weight: 17.9 kDa Accession Number: P01582 Gene ID: 16175 crossreactivity: Human, Mouse, Mouse + Chicken References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author McHale, J F Title Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: evidence for a dominant role of TNF-alpha. Citation Journal of immunology (Baltimore, Md. : 1950); 162(3) pg1648-55 PubMed Id 9973425 First Author Piseddu, I Title Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF. Citation Journal of immunology (Baltimore, Md. : 1950); 205(8) pg2056-2065 PubMed Id 32907996 First Author Draberova, H Title Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop. Citation The EMBO Journal; 39(17) pge104202 PubMed Id 32696476
