Wachstumsfaktoren & Zytokine

Recombinant Murine IL-1α

Product Details

Catalogue Number: 211-11A
Description:

IL-1α is a non-secreted, proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation  by inducing IL-2 release, B cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine.  Recombinant Murine IL-1α is a 17.9 kDa protein containing 156 amino acid residues.

Source: E.coli

Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)

AA Sequence: SAPYTYQSDL RYKLMKLVRQ KFVMNDSLNQ TIYQDVDKHY LSTTWLNDLQ QEVKFDMYAY SSGGDDSKYP VTLKISDSQL FVSAQGEDQP VLLKELPETP KLITGSETDL IFFWKSINSK NYFTSAAYPE LFIATKEQSR VHLARGLPSM TDFQIS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg.

Calculated Molecular Weight: 17.9 kDa

Accession Number: P01582

Gene ID: 16175

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
McHale, J F
Title
Vascular endothelial cell expression of ICAM-1 and VCAM-1 at the onset of eliciting contact hypersensitivity in mice: evidence for a dominant role of TNF-alpha.
Citation
Journal of immunology (Baltimore, Md. : 1950); 162(3) pg1648-55
PubMed Id
First Author
Piseddu, I
Title
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Citation
Journal of immunology (Baltimore, Md. : 1950); 205(8) pg2056-2065
PubMed Id
First Author
Draberova, H
Title
Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop.
Citation
The EMBO Journal; 39(17) pge104202
PubMed Id