Recombinant Murine IL-10 0 ReviewsSubmit a Review Product Details Catalogue Number: 210-10 Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Murine IL-10 is an 18.7 kDa protein of 161 amino acid residues. Source: E.coli Synonyms: B-TCGF, CSIF, TGIF AA Sequence: MSRGQYSRED NNCTHFPVGQ SHMLLELRTA FSQVKTFFQT KDQLDNILLT DSLMQDFKGY LGCQALSEMI QFYLVEVMPQ AEKHGPEIKE HLNSLGQKLK TLRMRLRRCH RFLPCENKSK AVEQVKSDFN KLEDQGVYKA MNEFDIFINC IEAYMMIKMK S Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: PeproTech's Murine IL-10 is fully biologically active as measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells. The ED50 was found to be ≤ 2 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. Calculated Molecular Weight: 18.7 kDa Accession Number: P18893 Gene ID: 16153 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation Allergy Transplantation product.subtitle.recentcitations First Author Di Carlo, S Title GM-CSF suppresses antioxidant signaling and drives IL-1β secretion through NRF2 downregulation. Citation EMBO reports; 23(8) pge54226 PubMed Id 35695080 First Author Spalinger, M R Title Loss of protein tyrosine phosphatase non-receptor type 2 reduces IL-4-driven alternative macrophage activation. Citation Mucosal Immunology; 15(1) pg74-83 PubMed Id 34420044 First Author Alexander, A F Title Single-cell secretion analysis reveals a dual role for IL-10 in restraining and resolving the TLR4-induced inflammatory response. Citation Cell Reports; 36(12) pg109728 PubMed Id 34551303
