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Recombinant Murine IL-11

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Product Details

Catalogue Number: 220-11
Description:
Recombinant Murine IL-11

IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts.  It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system.  IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells.  It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury.  Recombinant Murine IL-11 is a 19.1 kDa protein consisting of 179 amino acid residues.

Source: E.coli

Synonyms: AGIF (Adipogenesis inhibitory factor)

AA Sequence: MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine T11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Calculated Molecular Weight: 19.1 kDa

Accession Number: P47873

Gene ID: 16156

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Cova, G
Title
Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
Citation
The Journal of Experimental Medicine; 218(10)
PubMed Id
First Author
Ho, T T
Title
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
Citation
The Journal of Experimental Medicine; 218(7)
PubMed Id
First Author
Numata, A
Title
Lysine acetyltransferase Tip60 is required for hematopoietic stem cell maintenance.
Citation
Blood; 136(15) pg1735-1747
PubMed Id