Recombinant Murine IL-13 1 ReviewsSubmit a Review Product Details Catalogue Number: 210-13 Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 are cross-species reactive. Recombinant Murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues. Source: E.coli Synonyms: NC300 (Human), P600 (Murine) AA Sequence: MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 4.0 ng/ml, corresponding to a specific activity of ≥ 2.5 x 105 units/mg. Calculated Molecular Weight: 12.3 kDa Accession Number: P20109 Gene ID: 16163 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Cancer Immune System Inflammation Stem Cells & Differentiation Allergy product.subtitle.recentcitations First Author Park, I Title C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis. Citation Nature Communications; 13(1) pg215 PubMed Id 35017526 First Author Drurey, C Title Intestinal epithelial tuft cell induction is negated by a murine helminth and its secreted products. Citation The Journal of Experimental Medicine; 219(1) PubMed Id 34779829 First Author Dai, H Title Transcriptional neural-like signaling contributes to an immune-suppressive tumor microenvironment. Citation FASEB BioAdvances; 4(1) pg76-89 PubMed Id 35024574 product.subtitle.productreviews Existing reviews Works great for our research! We exclusively use Peprotech's recombinant proteins (human and murine). They have always performed well in our experiments and we have not had any issues yet. From: Kristen | Date: 08.07.2020 × Works great for our research! We exclusively use Peprotech's recombinant proteins (human and murine). They have always performed well in our experiments and we have not had any issues yet. From: Kristen | Date: 08.07.2020 Close
