Recombinant Murine IL-15

Product Details

Catalogue Number: 210-15

Description:

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Murine IL-15 is a 13.3 kDa protein consisting of 115 amino acid residues.

Source: E.coli

Synonyms: IL-T

AA Sequence: MNWIDVRYDL EKIESLIQSI HIDTTLYTDS DFHPSCKVTA MNCFLLELQV ILHEYSNMTL NETVRNVLYL ANSTLSSNKN VAESGCKECE ELEEKTFTEF LQSFIRIVQM FINTS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED₅₀ was determined by the stimulation of the proliferation of murine CTLL-2 cells is ≤ 5.0 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁵ units/mg.

Calculated Molecular Weight: 13.3 kDa

Accession Number: P48346

Gene ID: 16168

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

Note:

1mg will be provided as 2x500μg.

crossreactivity:

Human, Mouse, Rat

Country Of Origin: USA

Not for human use.

Research Interest

Stem Cells & Differentiation

product.subtitle.recentcitations

First Author

Borst, L

Title

NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division.

Citation

International Journal of Cancer; 150(4) pg688-704

PubMed Id

34716584

First Author

Hope, J L

Title

MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8⁺ T Cell Responses.

Citation

Journal of immunology (Baltimore, Md. : 1950); 208(3) pg603-617

PubMed Id

35022277

First Author

Evrard, M

Title

Sphingosine 1-phosphate receptor 5 (S1PR5) regulates the peripheral retention of tissue-resident lymphocytes.

Citation

The Journal of Experimental Medicine; 219(1)

PubMed Id

34677611

product.subtitle.productreviews

Existing reviews

Product with great consistency

We have been using this cytokine for splenic NK cells in numerous publications for the past 5 years. Great consistency!

From: Jin | Date: 21.07.2020

Works Like Magic

Have been using this cytokine for past 1year and has worked everytime. Very helpful for stimulating and expanding T cell population. Does a great job while performing in-vivo T cell transfer experiments.

From: Vineet | Date: 10.08.2020

Consistently great cytokine to keep mouse T cells happy

We routinely use this pro-survival homeostasis cytokine to generate mouse memory CD8+ T cells. The pricing and consistency of this cytokine can't be beat, and we have been using it for almost 20 years. All of our cytokines using in our lab are from peprotech.

From: Chirag | Date: 31.08.2020

Works very well to generate CD8 memory T cells

We have been using this cytokine for the last 5 years to generate CD8 memory T cells. It consistently provided very good differentiation profile in terms of surface marker expression, cytokine production and metabolic features.

From: mauro | Date: 19.08.2021

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