Recombinant Murine IL-17A 0 ReviewsSubmit a Review Product Details Catalogue Number: 210-17 Description: The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Murine IL-17A is a 30.0 kDa, disulfide-linked homodimer of two 133 amino acid, polypeptide chains. Source: E.coli Synonyms: IL-17, CTLA-8 AA Sequence (monomer): AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce IL-6 production by NIH 3T3 cells. Calculated Molecular Weight: 30 kDa Accession Number: Q62386 Gene ID: 16171 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Angiogenesis/Cardiovascular Immune System Inflammation product.subtitle.recentcitations First Author Hasebe, R Title ATP spreads inflammation to other limbs through crosstalk between sensory neurons and interneurons. Citation The Journal of Experimental Medicine; 219(6) PubMed Id 35579694 First Author Debackere, K Title Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified Citation Nature Communications; 12(1) pg3705 PubMed Id 34140493 First Author Senda, N Title HMGB1-mediated chromatin remodeling attenuates Il24 gene expression for the protection from allergic contact dermatitis. Citation Proceedings of the National Academy of Sciences of the United States of America; 118(1) PubMed Id 33443188
