Recombinant Murine IL-22 0 BewertungenSubmit a Review Produktdetails Katalognummer: 210-22 Beschreibung: IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10Rβ/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant Murine IL-22 is a 33.4 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains. Source: E.coli Synonyms: Interleukin-22, IL-TIF, Cytokine ZCYTO18 AA Sequence (monomer): MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce STAT3 activation in COLO 205 cells. The expected ED50 for this effect is 150-400 pg/ml. Calculated Molecular Weight: 33.4 kDa Accession Number: Q9JJY9 Gene ID: 50929 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest Immune System product.subtitle.recentcitations Erstautor Melin, N Titel Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury. Literaturstelle Cell death & disease; 12(4) pg366 PubMed ID 33824326 Erstautor Lindborg, J A Titel Optic nerve regeneration screen identifies multiple genes restricting adult neural repair. Literaturstelle Cell Reports; 34(9) pg108777 PubMed ID 33657370 Erstautor Shao, L Titel IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling Literaturstelle Cell Death & Disease; 11(11) pg970 PubMed ID 33177520