Recombinant Murine IL-33 0 ReviewsSubmit a Review Product Details Catalogue Number: 210-33 Description: IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-κB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant Murine IL-33 is a 17.5 kDa protein containing 158 amino acid residues. Source: E.coli Synonyms: Interleukin-33, IL-1 F11, NF-HEV AA Sequence: SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg. Calculated Molecular Weight: 17.5 kDa Accession Number: Q8BVZ5 Gene ID: 77125 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 100μg is the largest vial size for this product. Larger sizes supplied as multiple 50μg and/or 100μg vials. crossreactivity: Human, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Inflammation product.subtitle.recentcitations First Author Liu, C Title Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells Citation Cell Research; 31(10) pg1106-1122 PubMed Id 34239074 First Author Drube, S Title IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction. Citation Immunology; 163(1) pg86-97 PubMed Id 33427298 First Author Leimkühler, N B Title Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis. Citation Cell Stem Cell; 28(4) pg637-652.e8 PubMed Id 33301706
