Wachstumsfaktoren & Zytokine

Recombinant Murine IL-7

Product Details

Catalogue Number: 217-17
Description:

IL-7 is a hematopoietic growth factor that primarily affects early B and T cells.  Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors, such as ConA and IL-2.  Human and murine IL-7 are cross-species reactive.  Recombinant Murine IL-7 is a 15.0 kDa protein containing 130 amino acid residues.

Source: E.coli

Synonyms: Lymphopoietin 1(LP-1), pre-B cell factor

AA Sequence: MECHIKDKEG KAYESVLMIS IDELDKMTGT DSNCPNNEPN FFRKHVCDDT KEAAFLNRAA RKLKQFLKMN ISEEFNVHLL TVSQGTQTLV NCTSKEEKNV KEQKKNDACF LKRLLREIKT CWNKILKGSI

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Calculated Molecular Weight: 15 kDa

Accession Number: P10168

Gene ID: 16196

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Kauts, M
Title
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Citation
Stem Cell Reports; 11(4) pg1009-1020
PubMed Id
First Author
Rochman, Y
Title
Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 107(45) pg19455-60
PubMed Id
First Author
Lai, D
Title
KLF13 sustains thymic memory-like CD8(+) T cells in BALB/c mice by regulating IL-4-generating invariant natural killer T cells.
Citation
The Journal of Experimental Medicine; 208(5) pg1093-103
PubMed Id

product.subtitle.productreviews

Existing reviews
Works everytime
Happy to use this cytokine. Very efficient and economically priced. The product comes with all the relevant information and protocols on handling. Very helpful for expanding T cells and during ACT experiments.
From:  Vineet | Date:  10.08.2020
Great pro-survival cytokine for mouse T cells
We routinely use this great cytokine to generate mouse memory CD8+ T cells and also keep naive T cells alive. The pricing and consistency of this cytokine can't be beat.
From:  Chirag | Date:  31.08.2020