Recombinant Murine IP-10 (CXCL10) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-16 Description: IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant Murine IP-10 is an 8.7 kDa protein consisting of 77 amino acids, including the four conserved cysteine residues present in CXC chemokines. Source: E.coli Synonyms: γ-Interferon Inducible Protein-10, CXCL10, crg-2 AA Sequence: IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Assay #1:Determined by its ability to chemoattract IL-2 activated T cells using a concentration range of 0.1-10.0 ng/ml. Assay #2: Determined by its ability to chemoattract CXCR3-transfected HEK293 cells using a concentration range of 100-500 ng/ml. Calculated Molecular Weight: 8.7 kDa Accession Number: P17515 Gene ID: 15945 crossreactivity: Bacteria, Human, Monkey, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Shin, H Title CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2. Citation Nature Communications; 7 pg13346 PubMed Id 27827367 First Author Campanella, G S Title CXCR3 and heparin binding sites of the chemokine IP-10 (CXCL10). Citation The Journal of Biological Chemistry; 278(19) pg17066-74 PubMed Id 12571234 First Author Ha, Y Title Endoplasmic reticulum stress-regulated CXCR3 pathway mediates inflammation and neuronal injury in acute glaucoma. Citation Cell death & disease; 6 pge1900 PubMed Id 26448323
