Chemokine

Recombinant Murine LIX (CXCL6) (70 a.a.)

Product Details

Catalogue Number: 250-36
Description:

CXCL6, also known as LIX in mice, is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX, LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively. LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokines that binds to the CXCR1 and CXCR2 receptors. Recombinant Murine LIX is a 7.6 kDa protein consisting of amino acid residues 9-78 of the full length LIX protein (70 amino acids).

Source: E.coli

AA Sequence: TELRCVCLTV TPKINPKLIA NLEVIPAGPQ CPTVEVIAKL KNQKEVCLDP EAPVIKKIIQ KILGSDKKKA

Synonyms: CXCL6, GCP-2 (human), Granulocyte Chemotactic Protein-2

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 7.6 kDa

Accession Number: P50228

Gene ID: 20311

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Singh, K
Title
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Citation
Scientific Reports; 7(1) pg4267
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First Author
Rousselle, A
Title
CXCL5 limits macrophage foam cell formation in atherosclerosis.
Citation
The Journal of Clinical Investigation; 123(3) pg1343-7
PubMed Id
First Author
Mei, J
Title
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection.
Citation
Immunity; 33(1) pg106-17
PubMed Id