Recombinant Murine MIP-1α (CCL3) 0 BewertungenSubmit a Review Produktdetails Katalognummer: 250-09 Beschreibung: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Murine MIP-1α is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: Macrophage Inflammatory Protein-1 alpha, CCL3, LD78 alpha AA Sequence: APYGADTPTA CCFSYSRKIP RQFIVDYFET SSLCSQPGVI FLTKRNRQIC ADSKETWVQE YITDLELNA Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract murine balb/c splenocytes using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 7.8 kDa Accession Number: P10855 Gene ID: 20302 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Monkey, Mouse, References PubMed SDS Datenblattsuche Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Chemotaxis Immune System Inflammation Neurobiology Wound Healing Transplantation product.subtitle.recentcitations Erstautor Du, Y Titel Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation. Literaturstelle The Journal of Experimental Medicine; 219(7) PubMed ID 35640018 Erstautor Xiao, Y Titel Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Literaturstelle Cancer Cell; 39(3) pg423-437.e7 PubMed ID 33450198 Erstautor Galeano Niño, J L Titel Cytotoxic T cells swarm by homotypic chemokine signalling. Literaturstelle eLIFE; 9 PubMed ID 33046212