Recombinant Murine TNF-α 0 ReviewsSubmit a Review Product Details Catalogue Number: 315-01A Description: TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant Murine TNF-α is a soluble 156 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein. Source: E.coli Synonyms: Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin AA Sequence: MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the cytolysis of murine L929 cells in the presence of actinomycin D is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. Calculated Molecular Weight: 17.3 kDa Accession Number: P06804 Gene ID: 21926 crossreactivity: Cow, Human, Human + Hamster, Monkey, Mouse, Mouse + Bacteria, Mouse + Human, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Angiogenesis/Cardiovascular Apoptosis Cancer Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation TNF Superfamily Allergy Transplantation product.subtitle.recentcitations First Author Mócsai, A Title Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. Citation Journal of immunology (Baltimore, Md. : 1950); 162(2) pg1120-6 PubMed Id 9916742 First Author Munder, M Title Murine macrophages secrete interferon gamma upon combined stimulation with interleukin (IL)-12 and IL-18: A novel pathway of autocrine macrophage activation. Citation The Journal of Experimental Medicine; 187(12) pg2103-8 PubMed Id 9625771 First Author Sakai, S Title Inhibitory effect of ferulic acid on macrophage inflammatory protein-2 production in a murine macrophage cell line, RAW264.7. Citation Cytokine; 9(4) pg242-8 PubMed Id 9112332
