Recombinant Murine TPO 1 ReviewsSubmit a Review Product Details Catalogue Number: 315-14 Description: TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor, and acts as an important regulator of circulating platelets. Human and murine TPO exhibit cross-species reactivity. Recombinant Murine TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein. Source: E.coli Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF AA Sequence: SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg. Calculated Molecular Weight: 18.7 kDa Accession Number: P40226 Gene ID: 21832 crossreactivity: Human, Mouse, Mouse + Virus, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cell Culture Immune System Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Guo, S Title Complex oncogene dependence in microRNA-125a-induced myeloproliferative neoplasms. Citation Proceedings of the National Academy of Sciences of the United States of America; 109(41) pg16636-41 PubMed Id 23012470 First Author He, H Title Aging-induced IL27Ra signaling impairs hematopoietic stem cells. Citation Blood; 136(2) pg183-198 PubMed Id 32305041 First Author Zhao, L Title KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice. Citation Blood; 119(6) pg1511-21 PubMed Id 22160378 product.subtitle.productreviews Existing reviews Recombinant Murine SCF We use this product in our mouse media, it works well! From: Nichole | Date: 26.08.2020 × Recombinant Murine SCF We use this product in our mouse media, it works well! From: Nichole | Date: 26.08.2020 Close
