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Recombinant Murine TRAIL

Product Details

Catalogue Number: 315-19
Description:

TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL-induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins, and contain a cytoplasmic “death domain”, which activates the cell’s apoptotic machinery. Recombinant Murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF-homologous portion of the extracellular domain of the full length TRAIL protein.

Source: E.coli

Synonyms: TNF-Related Apoptosis-Inducing Ligand, TNFSF10, TL2

AA Sequence: MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Assay #1: Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100 ng/ml.

Assay #2: Measured by its ability to induce apoptosis in LN-18 cells (human glioblastoma cells). The expected ED50 for this effect is 40.0-60.0 ng/ml.

Calculated Molecular Weight: 20 kDa

Accession Number: P50592

Gene ID: 22035

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Liao, H
Title
TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment.
Citation
Cell Death & Disease; 10(2) pg77
PubMed Id
First Author
Kattah, M G
Title
A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival.
Citation
The Journal of Experimental Medicine; 215(7) pg1839-1852
PubMed Id
First Author
Nam, G
Title
Combined Rho-kinase inhibition and immunogenic cell death triggers and propagates immunity against cancer.
Citation
Nature Communications; 9(1) pg2165
PubMed Id