Recombinant Rat IL-10 0 ReviewsSubmit a Review Product Details Catalogue Number: 400-19 Description: IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells. Recombinant Rat IL-10 is an 18.7 kDa protein of 160 amino acid residues. Source: E.coli Synonyms: B-TCGF, CSIF, TGIF AA Sequence: SKGHSIKGDN NCTHFPVSQT HMLRELRAAF SQVKTFFQKK DQLDNIVLTD SLLQDFKGYL GCQALSEMIK FYLVEVMPQA ENHGPEIKEH LNSLGEKLKT LWIQLRRCHR FLPCENKSKA VEQVKNDFNK LQDKGVYKAM NEFDIFINCI EAYVTLKMKN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent inhibition of antigen-specific T cell proliferation is ≤10ng/ml. Calculated Molecular Weight: 18.7 kDa Accession Number: P29456 Gene ID: 25325 crossreactivity: Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation Allergy Transplantation product.subtitle.recentcitations First Author Bourdonnay, E Title Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling. Citation The Journal of Experimental Medicine; 212(5) pg729-42 PubMed Id 25847945 First Author Chen, H Title IL-10 Promotes Neurite Outgrowth and Synapse Formation in Cultured Cortical Neurons after the Oxygen-Glucose Deprivation via JAK1/STAT3 Pathway. Citation Scientific Reports; 6 pg30459 PubMed Id 27456198 First Author Schneider, D J Title Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication. Citation The Journal of Biological Chemistry; 292(51) pg20897-20910 PubMed Id 29101235
