Wachstumsfaktoren & Zytokine

Recombinant Rat IL-4

Product Details

Catalogue Number: 400-04
Description:

IL-4 is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. Produced by mast cells, T cells and bone marrow stromal cells, IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergy. Recombinant Rat IL-4 is a 14.0 kDa globular protein containing 126 amino acid residues.

Source: E.coli

Synonyms: BCGF, BCDF, B cell stimulating factor (BSF-1)

AA Sequence: MHGCNDSPLR EIINTLNQVT EKGTPCTEMF VPDVLTATRN TTENELICRA SRVLRKFYFP RDVPPCLKNK SGVLGELRKL CRGVSGLNSL RSCTVNESTL TTLKDFLESL KSILRGKYLQ SCTSMS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate proliferation of TF-1 cells.  The expected ED50 is 200-400 ng/ml.

Calculated Molecular Weight: 14 kDa

Accession Number: P20096

Gene ID: 287287

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Stangl, H
Title
MHC/class-II-positive cells inhibit corticosterone of adrenal gland cells in experimental arthritis: a role for IL-1β, IL-18, and the inflammasome
Citation
Scientific Reports; 10(1) pg17071
PubMed Id
First Author
Na, N
Title
Carbamylated erythropoietin regulates immune responses and promotes long-term kidney allograft survival through activation of PI3K/AKT signaling.
Citation
Signal Transduction And Targeted Therapy; 5(1) pg194
PubMed Id
First Author
Zogbi, C
Title
Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells.
Citation
Scientific Reports; 10(1) pg12350
PubMed Id