Chemokine

Recombinant Rat MCP-1 (CCL2)

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Product Details

Catalogue Number: 400-12
Description:
Recombinant Rat MCP-1 (CCL2)

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Rat MCP-1 is a 14.0 kDa protein containing 125 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine)

AA Sequence: QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 14 kDa

Accession Number: P14844

Gene ID: 24770

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Speth, J M
Title
Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation.
Citation
Journal of immunology (Baltimore, Md. : 1950); 196(12) pg5112-20
PubMed Id
First Author
Szmydynger-Chodobska, J
Title
Posttraumatic invasion of monocytes across the blood-cerebrospinal fluid barrier.
Citation
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism; 32(1) pg93-104
PubMed Id
First Author
Hinojosa, A E
Title
CCL2/MCP-1 modulation of microglial activation and proliferation.
Citation
Journal of Neuroinflammation; 8 pg77
PubMed Id