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Recombinant Rat VEGF165

Product Details

Catalogue Number: 400-31
Description:

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothellial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase(flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Rat VEGF165 is a 38.5 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

Source: E.coli

Synonyms: Vascular Endothelial Growth Factor, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF-A

AA Sequence (monomer): MAPTTEGEQK AHEVVKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNVTMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC). The expected ED50 is 4.0-8.0 ng/ml.

Calculated Molecular Weight: 38.5 kDa

Accession Number: P16612

Gene ID: 83785

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Lu, Y
Title
VEGF/Src signaling mediated pleural barrier damage and increased permeability contributes to subpleural pulmonary fibrosis.
Citation
American Journal of Physiology. Lung Cellular and Molecular Physiology; 320(6) pgL990-L1004
PubMed Id
First Author
Meeson, R
Title
VEGF with AMD3100 endogenously mobilizes mesenchymal stem cells and improves fracture healing.
Citation
Journal of orthopaedic research : official publication of the Orthopaedic Research Society; 37(6):1294-1302.
PubMed Id
First Author
Zhou, P
Title
Hypoxic preconditioning-induced autophagy enhances survival of engrafted endothelial progenitor cells in ischaemic limb.
Citation
Journal of Cellular and Molecular Medicine; 21(10) pg2452-2464
PubMed Id