Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein
Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellularproliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors andin postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin Acan be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Activin A binds to the two forms of activinreceptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Recombinant Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
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