Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein
Activin A is a TGF-β family member that exhibits a wide range of
biological activities, including regulation of cellular proliferation and
differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal
tumors and in postmenopausal women have been implicated in colorectal and
breast cancers, respectively. The
biological activities of Activin A can be neutralized by inhibins and by the
diffusible TGF-β antagonist,
follistatin. Activin A binds to the two
forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of
activin receptor type II (Act RII-A and Act RII-B). Activins are homodimers or heterodimers of
different β subunits. They are produced as
precursor proteins with an amino terminal propeptide that is cleaved to release
the C-terminal bioactive ligand.
Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of
two βA chains, each containing
116 amino acid residues.
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
(BTI‐Tn‐5B1‐4) Hi‐5 Insect cells*
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to inhibit the proliferation of
mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding
to a specific activity of ≥ 5 x 105 units/mg.
Chicken, Dog, Frog, Mouse, Human + Mouse, Human
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