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Recombinant Human/Murine/Rat Activin A (Insect derived)

Catalog Number:
120-14
Synonyms:
Inhibin beta-1, FRP, FSH (Follicle-stimulating hormone)-releasing protein
Description:
Activin A is a TGF-β family member that exhibits a wide range of biological activities, including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.  Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.  The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.  Activin A binds to the two forms of activin receptor type I (Act RI-A and Act RI-B) and two forms of activin receptor type II (Act RII-A and Act RII-B).  Activins are homodimers or heterodimers of different β subunits.  They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand.  Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.
AA Sequence:
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
Source:
(BTI‐Tn‐5B1‐4) Hi‐5 Insect cells*
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to inhibit the proliferation of mouse MPC-11 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Cross Reactivity:
Chicken, Dog, Frog, Mouse, Human + Mouse, Human
Research Interests:
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.
*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
Purchase This Product
  Size Price Qty
A 2µg 80.00 USD
B 10µg 195.00 USD
50µg 650.00 USD
100µg 1,200.00 USD
250µg 2,275.00 USD
500µg 3,900.00 USD
1mg 6,500.00 USD
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