Select Language:
Continue
Username:
Password:

Recombinant Human/Murine/Rat BDNF

Catalog Number:
450-02
Synonyms:
Brain Derived Neurotrophic Factor, Abrineurin
Description:
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions.
AA Sequence:
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
Cross Reactivity:
Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat, Human, Tadpole, Human + Virus, N/A
Research Interests:
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.
Purchase This Product
  Size Price Qty
A 2µg 80.00 USD
B 10µg 195.00 USD
50µg 624.00 USD
100µg 1,040.00 USD
250µg 1,820.00 USD
500µg 3,120.00 USD
1mg 5,200.00 USD
Add to Cart
Looking for a custom size? Click here