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Recombinant Human Activin B

Catalog Number:
120-15
Synonyms:
Activin beta-B, Inhibin beta-2
Description:
Activin B is a TGF-β family member that exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands.  Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II).  Activins are homodimers or heterodimers of different β subunits.  They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand.  Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.
AA Sequence:
GLECDGRTNL CCRQQFFIDF RLIGWNDWII APTGYYGNYC EGSCPAYLAG VPGSASSFHT AVVNQYRMRG LNPGTVNSCC IPTKLSTMSM LYFDDEYNIV KRDVPNMIVE ECGCA
Source:
(BTI‐Tn‐5B1‐4) Hi‐5 Insect cells*
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
Research Interests:
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.
*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
Purchase This Product
  Size Price Qty
A 1µg 80.00 USD
B 5µg 195.00 USD
50µg 1,176.00 USD
100µg 1,960.00 USD
250µg 3,430.00 USD
500µg 5,880.00 USD
1mg 9,800.00 USD
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