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Recombinant Human NT-3

Catalog Number:
450-03
Synonyms:
Neurotrophin-3, Neurotrophic factor, Nerve growth factor-2, NGF-2, HGNF
Description:
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  NT-3 is expressed by neurons of the central nervous systems, and can signal through the trk receptors.  NT-3 promotes the growth and survival of nerve and glial cells.  The amino acid sequences of human, murine and rat NT-3 are identical.  Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues).
AA Sequence:
MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
Cross Reactivity:
Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat, Human, Monkey, Human + Virus
Research Interests:
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.
Purchase This Product
  Size Price Qty
A 2µg 80.00 USD
B 10µg 195.00 USD
50µg 624.00 USD
100µg 1,040.00 USD
250µg 1,820.00 USD
500µg 3,120.00 USD
1mg 5,200.00 USD
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