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Recombinant Human NT-4

Catalog Number:
450-04
Synonyms:
Neurotrophin-4, Neurotrophic 4/5 (NT-4/NT-5)
Description:
NT-4 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  NT-4 is expressed in the prostate, thymus, placenta, and skeletal muscle.  NT-4 can signal through the LNGFR and trkB receptors, and promotes the survival of peripheral sensory sympathetic neurons.  Recombinant Human NT-4 is a noncovalently linked homodimer of two 14.0 kDa polypeptide monomers (260 total amino acid residues).
AA Sequence:
GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
Cross Reactivity:
Rat, Frog, Human, Mouse
Research Interests:
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.
Purchase This Product
  Size Price Qty
A 2µg 80.00 USD
B 10µg 195.00 USD
50µg 624.00 USD
100µg 1,040.00 USD
250µg 1,820.00 USD
500µg 3,120.00 USD
1mg 5,200.00 USD
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