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Recombinant Human Neurturin

Catalog Number:
450-11
Synonyms:
NTN, NRTN
Description:
Neurturin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, artemin, and persephin.  These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.  Neurturin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors.  Neurturin promotes the development and survival of sympathetic and sensory neurons by signaling through a receptor system composed of RET and GFRα2.  The functional form of human neurturin is a disulfide-linked homodimer, of two 11.8 kDa polypeptide monomers (204 total amino acid residues).  Each monomer contains seven conserved cysteine residues, one of which (Cys 69) is used for inter-chain disulfide bridging, and the others are involved in the intramolecular ring formation known as the cysteine knot configuration.
AA Sequence:
ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Human Neurturin at a concentration of 100 ng/ml will support the survival of 65% of newborn rat sympathetic neurons.
Cross Reactivity:
Mouse, Rat, Human
Research Interests:
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.
Purchase This Product
  Size Price Qty
A 5µg 80.00 USD
B 20µg 195.00 USD
100µg 600.00 USD
250µg 1,050.00 USD
500µg 1,800.00 USD
1mg 3,000.00 USD
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