APRIL, a member of the TNF superfamily, is expressed in monocytes, macrophages, certain transformed cell lines, certain cancers of the colon, and lymphoid tissues. APRIL, along with another TNF family member, BAFF, competes for two receptors, TACI and BCMA. APRIL has the ability to stimulate proliferation of various tumor cell lines, including Jurkat T cells and MCF-7 carcinoma cells. Like BAFF, APRIL also stimulates the proliferation of B and T cells. The human APRIL gene codes for at least four alternatively spliced transcriptional variants, which give rise to different isoforms of the APRIL precursor protein. All isoforms can be cleaved by the protease, furin, to release a soluble C-terminal fragment, which comprises the TNF-like receptor binding of the APRIL precursor. Recombinant Human APRIL is a soluble 16.3 kDa protein, consisting of 146 amino acid residues.
*Human APRIL(Catalog Number 310-10C) has replaced Human APRIL(Catalog Number 310-10)
Hi-5 Insect cells
A Proliferation-Inducing Ligand, TNFSF13, TRDL-1, TALL-2, CD256
AVLTQKQKKQ HSVLHLVPIN ATSKDDSDVT EVMWQPALRR GRGLQAQGYG VRIQDAGVYL LYSQVLFQDV TFTMGQVVSR EGQGRQETLF RCIRSMPSHP DRAYNSCYSA GVFHLHQGDI LSVIIPRARA KLNLSPHGTF LGFVKL
≥ 95% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to induce NF-κB activation in HEK293-NF-κB reporter cells transfected with BCMA receptor.
Calculated Molecular Weight:
50μg is the largest vial size for this product.
Larger sizes supplied as multiple 50μg vials.