Recombinant Human CDNF 0 ReviewsSubmit a Review Product Details Catalog Number: 450-05 Description: CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine-specific neurons. CDNF and its structural homolog, MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA-induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson's disease. Recombinant Human CDNF is an 18.5 kDa protein consisting of 162 amino acids, including 8 cysteine residues. Source: E.coli Synonyms: Cerebral Dopamine Neurotrophic Factor, ARMETL1 AA Sequence: MQEAGGRPGA DCEVCKEFLN RFYKSLIDRG VNFSLDTIEK ELISFCLDTK GKENRLCYYL GATKDAATKI LSEVTRPMSV HMPAMKICEK LKKLDSQICE LKYEKTLDLA SVDLRKMRVA ELKQILHSWG EECRACAEKT DYVNLIQELA PKYAATHPKT EL Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml. Calculated Molecular Weight: 18.5 kDa Accession Number: Q49AH0 Gene ID: 441549 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: This product is for research use only and not for cell, gene, or tissue therapy. Cross Reactivity Cited in References: Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Neurobiology Stem Cells & Differentiation Recent Citations First Author Venugopalan, P Title Transplanted neurons integrate into adult retinas and respond to light. Citation Nature Communications; 7 pg10472 PubMed ID 26843334 First Author Tsenkina, Y Title EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury. Citation Cell death & disease; 6 pge1922 PubMed ID 26469970
