Recombinant Human CNTF 0 ReviewsSubmit a Review Product Details Catalog Number: 450-13 Description: CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types, including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant Human CNTF is synthesized as a 199 amino acid polypeptide (22.8 kDa) lacking a hydrophobic N-terminal signal for secretion. Source: E.coli Synonyms: Ciliary Neurotrophic Factor AA Sequence: AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml. Calculated Molecular Weight: 22.8 kDa Accession Number: P26441 Gene ID: 1270 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Dog, Frog, Hamster, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Recent Citations First Author Fanning, S Title Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. Citation NPJ Parkinson's disease; 8(1) pg74 PubMed ID 35680956 First Author Lagomarsino, V N Title Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Citation Neuron; 109(21) pg3402-3420.e9 PubMed ID 34473944 First Author Singh, T Title Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated Citation Scientific Reports; 11(1) pg18916 PubMed ID 34556702
