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Neurotrophins

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Recombinant Human CNTF

Product Details

Catalog Number: 450-13
Description:

CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types, including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant Human CNTF is synthesized as a 199 amino acid polypeptide (22.8 kDa) lacking a hydrophobic N-terminal signal for secretion.

Source: E.coli

Synonyms: Ciliary Neurotrophic Factor

AA Sequence: AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml.

Calculated Molecular Weight: 22.8 kDa

Accession Number: P26441

Gene ID: 1270

Cross Reactivity Cited in References:
Dog, Frog, Hamster, Human, Mouse, Rat
Country Of Origin: USA

Not for human use.

Research Interest
Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing