Recombinant Human CNTF 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-13 Description: CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types, including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant Human CNTF is synthesized as a 199 amino acid polypeptide (22.8 kDa) lacking a hydrophobic N-terminal signal for secretion. Source: E.coli Synonyms: Ciliary Neurotrophic Factor AA Sequence: AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml. Calculated Molecular Weight: 22.8 kDa Accession Number: P26441 Gene ID: 1270 crossreactivity: Dog, Frog, Hamster, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Bone, Skeletal, Cartilage Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Ng, T K Title Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature. Citation Scientific Reports; 5 pg16429 PubMed Id 26549845 First Author Srikanth, P Title Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Citation Translational Psychiatry; 8(1) pg245 PubMed Id 30410030 First Author Liu, Z Title Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination. Citation Neuron; 102(3) pg587-601.e7 PubMed Id 30876848
