Recombinant Human Eotaxin (CCL11) 1 ReviewsSubmit a Review Product Details Catalogue Number: 300-21 Description: Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: CCL11 AA Sequence: GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-10.0 ng/ml. Calculated Molecular Weight: 8.3 kDa Accession Number: P51671 Gene ID: 6356 crossreactivity: Bacteria, Guinea Pig, Human, Human + Guinea Pig, Human + Hamster, Human + Mouse, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Neurobiology Wound Healing product.subtitle.recentcitations First Author Takeda, A Title CCR3 is a target for age-related macular degeneration diagnosis and therapy. Citation Nature; 460(7252) pg225-30 PubMed Id 19525930 First Author Zhang, Y Title A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma. Citation Scientific Reports; 7(1) pg15038 PubMed Id 29118379 First Author Tiffany, H L Title Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. Citation The Journal of Experimental Medicine; 186(1) pg165-70 PubMed Id 9207005 product.subtitle.productreviews Existing reviews Useful for western blot antibody validation Yielded a clean band at the expected molecular weight (~11kDa). From: Anthony | Date: 7/10/2020 × Useful for western blot antibody validation Yielded a clean band at the expected molecular weight (~11kDa). From: Anthony | Date: 7/10/2020 Close
