Chemokines

Recombinant Human Eotaxin (CCL11)

Product Details

Catalogue Number: 300-21
Description:

Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Source: E.coli

Synonyms: CCL11

AA Sequence: GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-10.0 ng/ml.

Calculated Molecular Weight: 8.3 kDa

Accession Number: P51671

Gene ID: 6356

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Takeda, A
Title
CCR3 is a target for age-related macular degeneration diagnosis and therapy.
Citation
Nature; 460(7252) pg225-30
PubMed Id
First Author
Zhang, Y
Title
A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.
Citation
Scientific Reports; 7(1) pg15038
PubMed Id
First Author
Tiffany, H L
Title
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.
Citation
The Journal of Experimental Medicine; 186(1) pg165-70
PubMed Id

product.subtitle.productreviews

Existing reviews
Useful for western blot antibody validation
Yielded a clean band at the expected molecular weight (~11kDa).
From:  Anthony | Date:  7/10/2020