Recombinant Human Eotaxin (CCL11) 1 ReviewsSubmit a Review Product Details Catalogue Number: 300-21 Description: Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines. Source: E.coli Synonyms: CCL11 AA Sequence: GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human peripheral blood eosinophils using a concentration range of 0.1-10.0 ng/ml. Calculated Molecular Weight: 8.3 kDa Accession Number: P51671 Gene ID: 6356 crossreactivity: Bacteria, Guinea Pig, Human, Human + Guinea Pig, Human + Hamster, Human + Mouse, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Neurobiology Wound Healing product.subtitle.recentcitations First Author Bonecchi, R Title Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-gamma in human neutrophils. Citation Journal of immunology (Baltimore, Md. : 1950); 162(1) pg474-9 PubMed Id 9886422 First Author Hamada, T Title Transendothelial migration of megakaryocytes in response to stromal cell-derived factor 1 (SDF-1) enhances platelet formation. Citation The Journal of Experimental Medicine; 188(3) pg539-48 PubMed Id 9687531 First Author Sallusto, F Title Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. Citation The Journal of Experimental Medicine; 187(6) pg875-83 PubMed Id 9500790 product.subtitle.productreviews Existing reviews Useful for western blot antibody validation Yielded a clean band at the expected molecular weight (~11kDa). From: Anthony | Date: 7/10/2020 × Useful for western blot antibody validation Yielded a clean band at the expected molecular weight (~11kDa). From: Anthony | Date: 7/10/2020 Close
