Recombinant Human EPO 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-64 Description: Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EPO in adult mammals are maintained primarily by the kidneys, whereas levels in fetal or neonatal mammals are maintained by the liver. EPO also can exert various non-hematopoietic activities, including vascularization and proliferation of smooth muscle, neural protection during hypoxia, and stimulation of certain B cells. PeproTech’s Human EPO contains 166 amino acid residues and has a calculated molecular weight of approximately 18.4 kDa. As a result of glycosylation, Recombinant Human EPO migrates with an apparent molecular mass of 37.0 kDa by SDS-PAGE gel, under reducing and non-reducing conditions. Source: CHO cells Synonyms: Erythropoietin, Epoetin AA Sequence: APPRLICDSR VLERYLLEAK EAENITTGCA EHCSLNENIT VPDTKVNFYA WKRMEVGQQA VEVWQGLALL SEAVLRGQAL LVNSSQPWEP LQLHVDKAVS GLRSLTTLLR ALGAQKEAIS PPDAASAAPL RTITADTFRK LFRVYSNFLR GKLKLYTGEA CRTGDR Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using TF-1 cells. The expected ED50 for this effect is 0.8-1.0 ng/ml. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 18.4 kDa Accession Number: P01588 Gene ID: 2056 crossreactivity: Human, Human + Virus, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Immune System Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Kauts, M Title Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells. Citation Stem Cell Reports; 11(4) pg1009-1020 PubMed Id 30197119 First Author Pavel-Dinu, M Title Gene correction for SCID-X1 in long-term hematopoietic stem cells. Citation Nature Communications; 10(1) pg1634 PubMed Id 30967552 First Author Uenishi, G I Title NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells. Citation Nature Communications; 9(1) pg1828 PubMed Id 29739946