Recombinant Human FGF-19 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-32 Description: The FGF family plays central roles during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-19, a member of the FGF family, is a high-affinity heparin-dependent ligand for FGFR4. FGF-19 is expressed during brain development and embryogenesis. Recombinant Human FGF-19 is a 21.8 kDa protein containing 195 amino acid residues. Source: E.coli Synonyms: Fibroblast Growth Factor-19, FGFJ AA Sequence: MRPLAFSDAG PHVHYGWGDP IRLRHLYTSG PHGLSSCFLR IRADGVVDCA RGQSAHSLLE IKAVALRTVA IKGVHSVRYL CMGADGKMQG LLQYSEEDCA FEEEIRPDGY NVYRSEKHRL PVSLSSAKQR QLYKNRGFLP LSHFLPMLPM VPEEPEDLRG HLESDMFSSP LETDSMDPFG LVTGLEAVRS PSFEK Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cell proliferation assay using balb/c 3T3 cells. The expected ED50 for this effect is 100-150 ng/ml. Calculated Molecular Weight: 21.8 kDa Accession Number: O95750 Gene ID: 9965 Note: 1mg will be provided as 2x500μg. crossreactivity: Chicken, Hamster, Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Bone, Skeletal, Cartilage Cancer FGF Superfamily Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Kanzaki, H Title The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma. Citation Scientific Reports; 11(1) pg5303 PubMed Id 33674622 First Author Xu, Y Title Fibroblast growth factor receptor 4 promotes progression and correlates to poor prognosis in cholangiocarcinoma. Citation Biochemical and Biophysical Research Communications; 446(1) pg54-60 PubMed Id 24565842 First Author Tomiyama, K Title Relevant use of Klotho in FGF19 subfamily signaling system in vivo. Citation Proceedings of the National Academy of Sciences of the United States of America; 107(4) pg1666-71 PubMed Id 20080590
