Growth Factors & Cytokines

Recombinant Human FGF-20

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Product Details

Catalogue Number: 100-41
Description:

FGF-20 is a secreted, heparin-binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-20 signals through FGFR 2c and 3c, and is expressed during limb and brain development. Recombinant Human FGF-20 is a 23.2 kDa protein containing 209 amino acid residues.

Source: E.coli

Synonyms: Fibroblast Growth Factor-20, FGFK

AA Sequence: PLAEVGGFLG GLEGLGQQVG SHFLLPPAGE RPPLLGERRS AAERSARGGP GAAQLAHLHG ILRRRQLYCR TGFHLQILPD GSVQGTRQDH SLFGILEFIS VAVGLVSIRG VDSGLYLGMN DKGELYGSEK LTSECIFREQ FEENWYNTYS SNIYKHGDTG RRYFVALNKD GTPRDGARSK RHQKFTHFLP RPVDPERVPE LYKDLLMYT

Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 5 ng/ml in the presence of 1µg/ml heparin, corresponding to a specific activity of ≥ 2 x 105 units/mg.

Calculated Molecular Weight: 23.2 kDa

Accession Number: Q9NP95

Gene ID: 26281

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Zhang, X
Title
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
Citation
The Journal of Biological Chemistry; 281(23) pg15694-700
PubMed Id
First Author
Savchenko, E
Title
FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes.
Citation
Scientific Reports; 9(1) pg9610
PubMed Id
First Author
Xiao, Z
Title
A computationally identified compound antagonizes excess FGF-23 signaling in renal tubules and a mouse model of hypophosphatemia.
Citation
Science Signaling; 9(455) pgra113
PubMed Id