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Growth Factors & Cytokines

Recombinant Human FGF-4

Product Details

Catalogue Number: 100-31
Description:
Recombinant Human FGF-4

FGF-4 is a heparin-binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-4 signals through FGFR 1c, 2c, 3c, and 4. Recombinant Human FGF-4 is a 19.7 kDa protein consisting of 182 amino acid residues.

Source: E.coli

Synonyms: Fibroblast Growth Factor-4, HST-1, Transforming protein KS3, HBGF-4

AA Sequence: GRGGAAAPTA PNGTLEAELE RRWESLVALS LARLPVAAQP KEAAVQSGAG DYLLGIKRLR RLYCNVGIGF HLQALPDGRI GGAHADTRDS LLELSPVERG VVSIFGVASR FFVAMSSKGK LYGSPFFTDE CTFKEILLPN NYNAYESYKY PGMFIALSKN GKTKKGNRVS PTMKVTHFLP RL

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 10 ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg.

Recombinant Human FGF-4 Biological Activity Graph

Calculated Molecular Weight: 19.7 kDa

Accession Number: P08620

Gene ID: 2249

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Capatina, N
Title
Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development.
Citation
Physiological Reports; 10(18) pge15467
PubMed Id
First Author
Ryu, T Y
Title
Human gut-microbiome-derived propionate coordinates proteasomal degradation via HECTD2 upregulation to target EHMT2 in colorectal cancer.
Citation
The ISME Journal; 16(5) pg1205-1221
PubMed Id
First Author
Muto, M
Title
Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 118(50)
PubMed Id

product.subtitle.productreviews

Existing reviews
Great Product
We have been using this FGF-4 product to culture Trophoblast stem cells successfully. Always arrives quickly and works well.
From:  Alison | Date:  8/7/2020