Recombinant Human Follistatin 0 ReviewsSubmit a Review Product Details Catalogue Number: 120-13 Description: Follistatin is a secreted protein that binds to ligands of the TGF-β family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as an activin antagonist whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-β ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant Human Follistatin is a 31.5 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain. Source: E.coli Synonyms: FS, Activin-binding protein AA Sequence: GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCN Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.1-0.4 µg/ml in the presence of 7.5 ng/ml Activin A. Calculated Molecular Weight: 31.5 kDa Accession Number: P19883 Gene ID: 10468 crossreactivity: Chicken, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Stem Cells & Differentiation product.subtitle.recentcitations First Author Harrington, A E Title Structural basis for the inhibition of activin signalling by follistatin. Citation The EMBO Journal; 25(5) pg1035-45 PubMed Id 16482217 First Author Cangkrama, M Title A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming. Citation EMBO Molecular Medicine; 12(4) pge11466 PubMed Id 32150356 First Author Yucer, N Title Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium. Citation Scientific Reports; 7(1) pg10741 PubMed Id 28878359
