Recombinant Human Follistatin 0 ReviewsSubmit a Review Product Details Catalog Number: 120-13 Description: Follistatin is a secreted protein that binds to ligands of the TGF-β family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as an activin antagonist whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-β ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant Human Follistatin is a 31.5 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain. Source: E.coli Synonyms: FS, Activin-binding protein AA Sequence: GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCN Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.1-0.4 µg/ml in the presence of 7.5 ng/ml Activin A. Calculated Molecular Weight: 31.5 kDa Accession Number: P19883 Gene ID: 10468 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Chicken, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Stem Cells & Differentiation Recent Citations First Author Wu, C Title Elevated circulating follistatin associates with an increased risk of type 2 diabetes Citation Nature Communications; 12(1) pg6486 PubMed ID 34759311 First Author Cangkrama, M Title A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming. Citation EMBO Molecular Medicine; 12(4) pge11466 PubMed ID 32150356 First Author Griffiths, R Title The Transcription Factor-microRNA Regulatory Network during hESC-chondrogenesis Citation Scientific Reports; 10(1) pg4744 PubMed ID 32179818
