Growth Factors & Cytokines

Recombinant Human gAcrp30/Adipolean

Product Details

Catalogue Number: 450-21
Description:

gAcrp30 is a naturally occurring globular protein obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, gAcrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and named AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver. Recombinant Human gAcrp30/Adipolean is a 16.6 kDa protein consisting of 145 amino acid residues.

Source: E.coli

Synonyms: APM-1, Adipolean (human), gad, globular domain of Acrp30

AA Sequence: MKGEPGEGAY VYRSAFSVGL ETYVTIPNMP IRFTKIFYNQ QNHYDGSTGK FHCNIPGLYY FAYHITVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the proliferation of murine M1 cells. The expected ED50 for this effect is 1.0-3.0 μg/ml.

Calculated Molecular Weight: 16.6 kDa

Accession Number: Q15848

Gene ID: 9370

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Dubessy, A
Title
Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS.
Citation
Glia; 67(12) pg2248-2263
PubMed Id
First Author
Tilija Pun, N
Title
Critical role of tristetraprolin and AU-rich element RNA-binding protein 1 in the suppression of cancer cell growth by globular adiponectin.
Citation
FEBS Open Bio; 8(12) pg1964-1976
PubMed Id
First Author
Hulsmans, M
Title
Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin.
Citation
PLoS ONE; 7(2) pge32794
PubMed Id