Growth Factors & Cytokines

Recombinant Human Galectin-1

Product Details

Catalogue Number: 450-39
Description:

Lectins, of either plant or animal origin, are carbohydrate-binding proteins that interact with glycoprotein and glycolipids on the surface of animal cells. The Galectins are lectins that recognize and interact with β-galactoside moieties. Galectin-1 is an animal lectin that has been shown to interact with CD3, CD4, and CD45. It induces apoptosis of activated T cells and T leukemia cell lines, and inhibits the protein phosphatase activity of CD45. Recombinant Human Galectin-1 is a 14.5 kDa protein containing 134 amino acid residues.

Source: E.coli

Synonyms: Galactose-specific lectin-1, Beta-galactoside-binding lectin L-14-I, Galaptin, 14 kDa lectin, S-LAC lectin-1

AA Sequence: ACGLVASNLN LKPGECLRVR GEVAPDAKSF VLNLGKDSNN LCLHFNPRFN AHGDANTIVC NSKDGGAWGT EQREAVFPFQ PGSVAEVCIT FDQANLTVKL PDGYEFKFPN RLNLEAINYM AADGDFKIKC VAFD

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human blood monocytes. Chemotactic activity was observed at a concentration of 2.5 µg/ml with a peak response obtained at 250 µg/ml.

Calculated Molecular Weight: 14.5 kDa

Accession Number: P09382

Gene ID: 3956

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Freitag, N
Title
Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 110(28) pg11451-6
PubMed Id
First Author
Carlos, C P
Title
Pharmacological treatment with galectin-1 protects against renal ischaemia-reperfusion injury.
Citation
Scientific Reports; 8(1) pg9568
PubMed Id
First Author
Sweeney, J G
Title
Loss of GCNT2/I-branched glycans enhances melanoma growth and survival.
Citation
Nature Communications; 9(1) pg3368
PubMed Id

product.subtitle.productreviews

Existing reviews
good ELISA results
Used for ELISA binding assay, got good results. Did not do any assays for function.
From:  Lucia | Date:  8/3/2021