Recombinant Human GDF-3 0 ReviewsSubmit a Review Product Details Catalogue Number: 120-22 Description: GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia that characterizes Type 2 diabetes. Recombinant Human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains. Source: E.coli Synonyms: Growth/Differentiation Factor-3, Vgr-2, UNQ2222/PRO248 AA Sequence (monomer): AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml. Calculated Molecular Weight: 26 kDa Accession Number: Q9NR23 Gene ID: 9573 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Frog, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cell Culture Diabetes/Weight Regulation Immune System Stem Cells & Differentiation TGF-β Superfamily product.subtitle.recentcitations First Author Levine, A J Title GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses. Citation Developmental Biology; 325(1) pg43-8 PubMed Id 18823971
