Chemokines

Recombinant Human HCC-1 (CCL14) (72 a.a.)

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Product Details

Catalogue Number: 300-38
Description:


Recombinant Human HCC-1 (CCL14) (72 a.a.)

HCC-1 is a CC chemokine that signals through the CCR1 receptor and chemoattracts blood monocytes. It is secreted by various tissues, including skeletal muscle, heart, spleen, liver and bone marrow. Mature HCC-1 is found in four different forms, which are distinguished by differential N-terminal trucation and contain 74, 72, 71, or 66 amino acid residues. Recombinant Human HCC-1 is an 8.4 kDa protein consisting of 72 amino acids, including the four highly conserved residues present in CC chemokines.

Source: E.coli

Synonyms: Hemofiltrate CC Chemokine-1, CCL14, HCC-1/HCC-3, NCC-2

AA Sequence: TESSSRGPYH PSECCFTYTT YKIPRQRIMD YYETNSQCSK PGIVFITKRG HSVCTNPSDK WVQDYIKDMK EN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 5.0-20.0 ng/ml.

Calculated Molecular Weight: 8.4 kDa

Accession Number: Q16627

Gene ID: 6358

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Singh, K
Title
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Citation
Scientific Reports; 7(1) pg4267
PubMed Id
First Author
Alenazi, Y
Title
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Citation
Scientific Reports; 8(1) pg6333
PubMed Id
First Author
Lee, A W
Title
A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.
Citation
The Journal of Biological Chemistry; 294(29) pg11199-11212
PubMed Id