Recombinant Human I-TAC (CXCL11) 0 ReviewsSubmit a Review Product Details Catalog Number: 300-46 Description: I-TAC is a 'non-ELR' CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2 activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, or monocytes. Recombinant Human I-TAC is an 8.3 kDa protein containing 73 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines. Source: E.coli Synonyms: Interferon Inducible T-Cell α Chemokine, CXCL11, B-R1 AA Sequence: FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract IL-2-activated T-cells using a concentration range of 0.1-10.0 ng/ml. Calculated Molecular Weight: 8.3 kDa Accession Number: O14625 Gene ID: 6373 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Cross Reactivity Cited in References: Bacteria, Hamster, Human, Monkey, Mouse, Rabbit References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Wound Healing Recent Citations First Author Meyrath, M Title The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides Citation Nature Communications; 11(1) pg3033 PubMed ID 32561830 First Author Lee, A W Title A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins. Citation The Journal of Biological Chemistry; 294(29) pg11199-11212 PubMed ID 31167786 First Author Tulic, M Title Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo. Citation Nature Communications; 10(1) pg2178 PubMed ID 31097717
