Recombinant Human IFN-β 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-02BC Description: Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN-α is an acid-stable molecule that signals through IFN-α/βR, which is also used by IFN-β. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN-α contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity. PeproTech’s Recombinant Human IFN-β is a 20.0 kDa protein containing 166 amino acid residues. Due to glycosylation, IFN-β has an approximate MW of 22.3 kDa based on SDS-PAGE gel and Mass Spectrometry. *Human IFN-β (Catalog Number 300-02BC) has replaced Human IFN-β (Catalog Number 300-02B) Source: CHO cells Synonyms: Fibroblast Interferon, IFNB1, Type I Interferon AA Sequence: MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY CLKDRMNFDI PEEIKQLQQF QKEDAALTIY EMLQNIFAIF RQDSSSTGWN ETIVENLLAN VYHQINHLKT VLEEKLEKED FTRGKLMSSL HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI LRNFYFINRL TGYLRN Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by a cytotoxicity assay using human TF-1 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 20 kDa Accession Number: P01574 Gene ID: 3456 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Monkey, Mouse, Pig References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 AIDS/HIV Cancer Immune System Neurobiology product.subtitle.recentcitations First Author Jiménez-Andrade, Y Title The Developmental Transcription Factor p63 Is Redeployed to Drive Allergic Skin Inflammation through Phosphorylation by p38α. Citation Journal of immunology (Baltimore, Md. : 1950); 208(12) pg2613-2621 PubMed Id 35623662 First Author Yan, K Title Haploinsufficiency of PSMD12 Causes Proteasome Dysfunction and Subclinical Autoinflammation. Citation Arthritis & rheumatology (Hoboken, N.J.); 74(6) pg1083-1090 PubMed Id 35080150 First Author Zheng, X Title AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus. Citation The EMBO Journal; 41(6) pge108016 PubMed Id 35191555
