Recombinant Human IGF-BP2 0 ReviewsSubmit a Review Product Details Catalog Number: 350-06B Description: IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich, secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant Human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. Source: (BTI-Tn-5B1-4) Hi-5 Insect cells Synonyms: Insulin-like Growth Factor-Binding Protein 2, IBP-2 AA Sequence: EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells. Calculated Molecular Weight: 31.5 kDa Accession Number: P18065 Gene ID: 3485 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. Cross Reactivity Cited in References: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Cancer Diabetes/Weight Regulation Recent Citations First Author Stephenson, S Title Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells. Citation Journal of immunology (Baltimore, Md. : 1950); 202(4) pg1287-1300 PubMed ID 30642980 First Author Qin, E Y Title Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma. Citation Cell; 170(5) pg845-859.e19 PubMed ID 28823557 First Author Nixon, C C Title Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected]. Citation Scientific Reports; 5 pg8670 PubMed ID 25728014
