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Growth Factors & Cytokines

Recombinant Human IGF-I

Product Details

Catalogue Number: 100-11
Recombinant Human IGF-I

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro.  IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times.  The IGFs belong to the Insulin gene family, which also contains insulin and relaxin.  The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin.  IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone.  Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor.  Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.  Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-I is 7.6 kDa.     

Source: E.coli

Synonyms: Insulin-like Growth Factor-I, Somatamedin C, IGF-IA


Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Recombinant Human IGF-I WHO Comparison Graph Recombinant Human IGF-I Biological Activity Graph

Calculated Molecular Weight: 7.6 kDa

Accession Number: P05019

Gene ID: 3479

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

Country Of Origin: USA

Not for human use.

Research Interest


First Author
Chen, W
Reprogramming of human peripheral blood mononuclear cells into induced mesenchymal stromal cells using non-integrating vectors.
Communications Biology; 6(1) pg393
PubMed Id
First Author
Pinto-Benito, D
IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner.
Glia; 70(6) pg1153-1169
PubMed Id
First Author
Li, T
Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies.
Cell Proliferation; 55(4) pge13212
PubMed Id


Existing reviews
IGF-1 for Endometrial Organoid Culture
Successfully cultured Endometrial Organoids using IGF-1 and HGF from Peprotech.
Quick Overnight Delivery is great.
From:  Hardik | Date:  8/31/2020