Growth Factors & Cytokines

Recombinant Human IGF-I

Product Details

Catalogue Number: 100-11
Description:


Recombinant Human IGF-I

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro.  IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times.  The IGFs belong to the Insulin gene family, which also contains insulin and relaxin.  The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin.  IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone.  Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor.  Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.  Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. The calculated molecular weight of Recombinant Human IGF-I is 7.6 kDa.     

Source: E.coli

Synonyms: Insulin-like Growth Factor-I, Somatamedin C, IGF-IA

AA Sequence: GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 7.6 kDa

Accession Number: P05019

Gene ID: 3479

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Kauts, M
Title
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Citation
Stem Cell Reports; 11(4) pg1009-1020
PubMed Id
First Author
Ng, T K
Title
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Citation
Scientific Reports; 5 pg16429
PubMed Id
First Author
Liu, L
Title
Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways.
Citation
Oncogene; 25(53) pg7029-40
PubMed Id

product.subtitle.productreviews

Existing reviews
IGF-1 for Endometrial Organoid Culture
Successfully cultured Endometrial Organoids using IGF-1 and HGF from Peprotech.
Quick Overnight Delivery is great.
From:  Hardik | Date:  8/31/2020